Madame Medusa is a member of the Villain League and is the main villain of the Rescuers.
Medusa is described as greedy and obsessed. She is also very crazy, ill-tempered and sometimes unstable; which makes her intimidating at times. However, she has a bit of a bumbling nature, which makes a little hard for people to take her seriously as a really scary villain. She is very intelligent and patient, but when she comes to the point of losing it, she is not someone you want to be around. She will stop at nothing to get what she wants; such as using Penny, a little girl, to go down into a dark cave just to retrieve the Devil's Eye.
Prior to the film, Medusa discovers that the world's largest diamond, the Devil's Eye, is buried deep underground in a pirate's cave in Devil's Bayou. Much to her disappointment, the cave entrance is much too narrow for her to fit through. Neither her incompetent henchman, Mr. Snoops, nor her 2 pet crocodiles Brutus and Nero, can fit through. It is then that the witch decides to return to New York City, where her pawnshop is located, and abducts the poor orphan Penny to fetch the diamond for her. 3 months later (when the film The Rescuers introduces her), Medusa finds that although Snoops has managed to force Penny down into the cave, he is unable to persuade her to search. Moreover, he has caught the little girl sending out messages in bottles. Medusa, frustrated with Mr. Snoops’ inability to manage an orphan girl, takes the next flight back to Devil's Bayou to take charge.
Upon arriving, Medusa made things even more miserable for Penny, so much so that Penny attempted to run away numerous times, only to be caught by Medusa and her two faithful crocodiles every time. Medusa lost her patience with Penny and declared that no matter what, Penny would find the Devil's Eye, and would stay underground until she did so, regardless of the danger.
Prior to their search, Bernard and Miss Bianca from the Rescue Aid Society in New York arrive to try to save Penny, but Medusa panics upon the sight of them and nearly blows them away with her shotgun. This fails however, as the two mice escape and soon afterwards meet Penny face-to-face.
She ultimately forces Penny down into the cave, holding her teddy bear hostage, and refusing to lift her back out until she has found and retrieved the diamond. Since the cave fills with water at each high tide, Penny was aware that Medusa's threat was a potentially lethal one. She was accompanied by Bernard and Miss Bianca and with their help, she found the Devil's Eye. Unfortunately, it was stuck in the skull of a dead pirate and they could not get it out, but Medusa refused to hoist Penny up until she retrieved it. With the tide rising and the waters splashing violently, Penny and the mice recovered the diamond by opening the skull with a sword, and were lifted back to the surface just in time. Medusa immediately indulged in her newfound wealth, refusing to let Snoops so much as look at it. The group made their way to the riverboat where Medusa planned her escape.
While Miss Bianca and Bernard called their swamp friends for help, Medusa held Penny and Snoops at gunpoint, intending to escape with the diamond herself (Which she hid in Penny's teddy bear). However, the two mice literally trip Medusa up, allowing Penny to grab the diamond and make a run for it. Medusa and her crocs fought the animals slowing her down but was easily overpowered, and was soon at the mercy of Mr. Snoops' fireworks after the animals set them off.
Penny fled in Medusa's swampmobile, but Medusa refused to give up, and pursued Penny by water skiing. She ran into her two crocs and whipped them with a rope to get them to move faster, much to their anger. However, Penny was able to escape and Medusa was sent flying into her riverboat, which was now sinking due to the fireworks display. Medusa watched in defeat as Penny and the animals escaped with the Devil's Eye, leaving her to face the angered Brutus and Nero alone while Mr. Snoops fled the scene.
It was never shown if Medusa was able to escape the crocodiles.
Role in the series
she was a minor member of the villain leage, who betreyed them to keep the dimond to herself, but when defeated however, she begged Dark Cynder for forgiveness, which Dark Cynder refused, and left her to be presumed eaten by Medusa's own pet gaters. But since Mirage has a much more awareness for the usefulness of all villains, she has forgiven medusa for her betrayal and has given her and Mr. Snoops orders to infiltrate Max's college to try and destroy Spongebob and his friends at the college X-games.